WHOLESOME CLINIC
Integrative Psychiatry & Wellness
Whole Mind. Whole Body. Wholesome.
In-person care in Frisco, TX • Telehealth in TX, CO, NM, OK, LA , OR & AR
Depression care pathways • Adults 18+

Treatment-Resistant Depression Treatment in Frisco, TX

If depression hasn't improved enough after antidepressant medication, therapy, or other prior treatment, a treatment-resistant depression evaluation can help identify what to try next. We start with a structured psychiatric evaluation and build a clear plan, and when clinically appropriate, we may discuss advanced in-office options, including Spravato (esketamine).

In-person care in Frisco Adults 18+ Most major insurance accepted Same-week appointments when available
Important: This page is for education and scheduling support. Individual recommendations are made after a clinical evaluation. If an in-office treatment is recommended, it is provided in Frisco and may require monitoring and a ride home.

Serving Frisco and Nearby North Dallas Communities

We welcome adults from Frisco, Celina, McKinney, Prosper, Little Elm, The Colony, Allen, Carrollton, Lewisville, and North Dallas. In-person services are provided at our Frisco office.

Address: 7978 Preston Rd, Suite 804, Frisco, TX 75034 • Get directions

What does "Treatment-Resistant Depression (TRD)" mean?

"Treatment-resistant depression" commonly means depression symptoms haven't improved enough after trying two or more depression treatments at an appropriate dose and duration. Many people aren't sure whether their prior trials "count" — that's something we clarify during the evaluation.

If you're unsure, you're still in the right place. We'll review your history and recommend practical next steps.

Adults only: This page is for patients 18+. If you're seeking care for a child or teen, please call and we'll guide you to the right next step.

Signs depression may need a different approach

You don't need to know the term "TRD" to reach out. Many people simply feel stuck or discouraged after trying multiple options.

  • You've tried multiple medications with limited relief
  • Symptoms improve briefly, then return
  • Side effects make it hard to stay on a helpful dose
  • You're still struggling with sleep, motivation, focus, or daily functioning
  • Depression continues to affect work, relationships, or self-care despite treatment efforts

Check fit (30 seconds)

Treatment-Resistant Depression Evaluation in Frisco, TX — Options we may discuss

TRD isn't one-size-fits-all. Your plan is based on your history, symptoms, prior treatment response, safety screening, and goals.

Medication optimization & augmentation

We review what you've tried, how you responded, and side effects to guide a more strategic medication plan.

Therapy coordination & support

When appropriate, we may recommend evidence-based therapy support alongside medication-based care. With your consent, we can coordinate with your therapist.

Advanced treatment options: For eligible adults with treatment-resistant depression, we may discuss advanced treatment options including Spravato (esketamine). Spravato treatment is provided in our Frisco clinic under clinical supervision when appropriate.

Learn about Spravato treatment in Frisco →

What to expect at your evaluation

Your evaluation is designed to give you clarity and a real plan. We'll review your symptoms, history, and prior treatment response, then outline next steps and a follow-up approach.

During the visit

  • Review symptoms, history, and goals
  • Medication review (what helped, what didn't, and side effects)
  • Screen for factors that can affect treatment choices
  • Discuss evidence-based options and next steps

What to bring

  • A list of treatments you've tried (or pharmacy history)
  • Prior psychiatric records (if available)
  • Insurance card (if using insurance)
Safety note: If you're experiencing an emergency or feel you may harm yourself, call 911 or go to the nearest emergency room.

Who is a fit for (and who we may not be)

This page is designed to help you self-select the right next step. We'll confirm the best care plan after a clinical evaluation.

We're likely a good fit if you:

  • Are an adult (18+) seeking a structured depression evaluation
  • Have tried prior depression treatments and still don't feel well enough
  • Want a clear plan with evidence-based next steps
  • Can attend in-person visits in Frisco if an in-office treatment is recommended
  • Prefer a clinic that explains options, expectations, and safety requirements upfront

We may not be the best fit if you:

  • Need emergency or crisis care right now (call 911 or go to the nearest ER)
  • Are seeking a guaranteed treatment or a specific medication without evaluation
  • Cannot attend in-person visits in Frisco if an in-office option is recommended
  • Are looking for ongoing weekly psychotherapy (we can coordinate, but we are not a therapy-only practice)
Quick note: If you're unsure, that's okay — book an evaluation and we'll help clarify the most appropriate next step.

What happens after the evaluation

Our goal is to leave you with clarity and a plan. Your next steps depend on your history, safety screening, and clinical assessment.

Possible next steps may include:

  • Medication adjustments or augmentation strategies
  • Coordinating therapy support (with your consent)
  • Follow-up visits to track response and refine the plan
  • If clinically appropriate, discussing advanced in-office options and the steps required

If an in-office option is recommended

  • We'll review logistics, safety requirements, and monitoring expectations
  • We'll outline insurance documentation/prior authorization steps when needed
  • We'll confirm scheduling availability and what to bring to visits
Important: Individual recommendations are made after a clinical evaluation. Not every patient is a candidate for every option.

Insurance, cost & next steps

Coverage and requirements vary by plan. If a treatment requires documentation or prior authorization, our team can help you understand the process and next steps.

  1. Book an evaluation
  2. Verify benefits (if using insurance)
  3. Review your personalized plan
  4. If indicated, we support prior-authorization steps for treatments such as Spravato

Prefer to talk to someone first? Call 972-905-9435.

Check fit (quick, non-clinical)

This quick check helps you choose the right appointment type. Please don't include private medical details on this page. Final recommendations are made after a clinical evaluation.

Quick fit check (30 seconds)

If you are in crisis or thinking about self-harm, call 911 or go to the nearest emergency room.

Frequently asked questions

What qualifies as treatment-resistant depression?

Treatment-resistant depression commonly refers to symptoms that haven't improved enough after trying two or more depression treatments at an appropriate dose and duration. A clinician confirms whether this applies based on your treatment history.

How do I know if I'm eligible for Spravato?

Eligibility depends on diagnosis, prior treatment history, safety screening, and clinical assessment. If appropriate, we'll also review monitoring requirements and insurance steps.

Do you serve patients outside Frisco?

Yes. We commonly see patients from McKinney, Prosper, Little Elm, The Colony, Aubrey, Celina, Melissa, Anna, Allen, Carrollton, Lewisville, and North Dallas. In-person services are provided at our Frisco office.

Does insurance cover TRD care?

Coverage varies by plan and by treatment type. We can help you understand benefits and, when needed, documentation or prior-authorization steps.

Telehealth vs in-person: what to know

We offer both telehealth and in-person evaluations for adults, depending on clinical needs and appointment availability. If an in-office treatment is recommended, it is provided in Frisco.

Evaluation options

  • Telehealth evaluation: convenient first step for many patients
  • In-person evaluation: available at our Frisco office

In-office treatments

  • If recommended, in-office treatments are provided in Frisco
  • Some treatments may require monitoring and a ride home

Not sure which evaluation type to choose? Use the quick fit check or call 972-905-9435.

Meet Your Provider

Stephanie Ukoha, DNP, FNP-BC, PMHNP-BC - Psychiatric and Family Care Specialist
Managing Clinician

Stephanie Ukoha, DNP, FNP-BC, PMHNP-BC

Dual-Board-Certified Family & Psychiatric Nurse Practitioner

Stephanie Ukoha provides comprehensive treatment-resistant depression (TRD) evaluations for adults in Frisco, TX, and surrounding North Texas communities. She carefully reviews each patient's mental health history, prior medication trials, therapy experiences, current symptoms, and overall medical profile to determine appropriate next steps in care. Her approach emphasizes thorough assessment, evidence-based treatment planning, and consideration of advanced treatment options, including Spravato (esketamine), when clinically appropriate.

DNP (Doctor of Nursing Practice) PMHNP-BC (Psychiatric Specialist) FNP-BC (Family Medicine Integration)

Book an evaluation — Treatment-Resistant Depression Evaluation in Frisco, TX

Please choose the appointment type that best matches your goal. All options below are evaluations. Individual recommendations are made after a clinical assessment, and not every patient is a candidate for every option.

Which appointment should I choose?

Use this guide to choose the evaluation that best matches your goal. If you are unsure, start with a TRD Consultation or call our team for help.

Choose a TRD Consultation if:

  • You are not sure whether you qualify for Spravato
  • You want a full review of depression treatment options
  • You have tried medications but still feel stuck
  • You are unsure whether your medication history meets criteria

Choose Initial Spravato Consultation if:

  • You specifically want to discuss Spravato
  • You have tried at least two antidepressants
  • You can attend in-office treatment in Frisco
  • You can arrange transportation home after treatment
Not sure which to choose? Schedule a TRD Consultation or call 972-905-9435 and our team can help guide you.

Prefer to schedule by phone? Call 972-905-9435.

For Therapists & Primary Care Clinicians

Helpful referral information includes diagnosis, medication history, current medications, safety concerns, treatment response, and the reason for referral, such as TRD evaluation, Spravato consideration, medication optimization, or second opinion. You may call 972-905-9435 to discuss a referral.

How to refer

  • Ask the patient to schedule online on this page, or call 972-905-9435
  • Send relevant records with the patient's written consent
  • Include diagnosis, prior treatment trials, and current concerns (as available)

What we provide back (with consent)

  • Confirmation of evaluation completion
  • Care plan summary and recommendations
  • Coordination notes for continuity of care
Questions about a referral? We're happy to discuss whether a patient may be a fit.
Call 972-905-9435
Treatment-resistant depression treatment in Frisco TX